Resources for Genealogists and Journalists to Learn More About Interpreting DNA-Driven Tests














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Resources for Ancestry and/or Nutritional Genomics

 

 How to Open a DNA-Driven Genealogy Reporting Service

DNA-Driven Genealogy Books

 

How to Open DNA-Driven Genealogy Reporting & Interpreting Businesses: Applying Your Communications Skills to Popular Health or Ancestry Issues in the News

Publisher's price: $23.95
Format: Paperback
Size: 6 x 9
Pages: 398
ISBN: 0-595-44278-1
Published: Apr-2007
 

ASJA Press, 1-800-AUTHORS
International orders:
Call 00-1-402-323-7800
Open your online DNA-driven genealogy reporting service business. The laboratory you contract with does testing and sends you reports that you interpret for your clients.
Book Description
       Here's how to open your own online DNA-driven genealogy reporting/interpreting service business. You wouldn't do the actual DNA testing. The laboratory you contract with does the testing and sends you reports that you interpret for your clients.
As a DNA-driven genealogist, you would prepare illustrated and text-driven reports, colorful CDs, brochures, press kits, covers, Web sites, and guides to interpreting the DNA-for-ancestry-based information. You would interpret tests for deep ancestry to your clients.
       What verbal skills and any other preparation would you need to empower consumers with knowledge from reports you receive from your partnering DNA-testing laboratory? Would you also interpret reports from genetics counselors testing for predisposition to diseases? Or emphasize only deep ancestry?
Would you need a self-taught science background, a genealogy hobby, or only marketing and communications experience? Who does the actual interpreting? How would you contract with DNA laboratories to send reports and other information related to ancestry?
       You may be a genealogist, a personal historian, or a life story videographer thinking of partnering with a DNA-testing laboratory. Your business would be to make complex information easy to understand and interpret in plain language DNA reports from scientists to genealogy clients and surname groups. The DNA tests could be for ancestry and/or nutritional genomics issues.

http://www.iuniverse.com/bookstore/book_detail.asp?&isbn=0-595-44278-1
















 

 


E-Letter from Bryan Sykes:

From: Bryan Sykes
To: Anne Hart
Sent: Wednesday, December 01, 2004 4:28 PM

Subject: Re: Thank you for starting us to search for English ancestors

Dear Anne
Well I suppose that’s what academics are for. I’m so thrilled that my research has led to something useful. It certainly didn’t seem so at the time.

On a serious vein, what has happened in ‘genetic genealogy’ is extremely unusual. Blue sky scientific research has opened up a field which is now being championed by yourself and others. The research that counts is now being done by enthusiastic practitioners – mainly unpaid. It is the return of the long forgotten 19th century paragon – the amateur scientist. I feel a ponderous and pompous article coming on!
Best wishes – and a very happy Christmas.

Bryan
 


DNA-Driven Genealogy: How to Find Information

International orders:
Contact iUniverse
 
 
Popular Health & Medical Writing for Magazines : How to Turn Current Research & Trends into Salable Feature Articles
Publisher's price: $16.95
Format: Paperback
Size : 6 x 9
Pages: 236
ISBN: 0-595-35178-6
Published: Apr-2005
 
 
Publisher's price: $19.95
Format: Paperback
Size : 6 x 9
Pages: 287
ISBN: 0-595-36539-6
 
 
Predictive Medicine for Rookies: Consumer Watchdogs, Reviews, & Genetics Testing Firms Online
Publisher's price: $23.95
Format: Paperback
Size : 6 x 9
Pages: 402
ISBN: 0-595-35146-8
Published: Apr-2005
 
 
Publisher's price: $33.95
Format: Paperback
Size : 6 x 9
Pages: 656
ISBN: 0-595-31684-0
Published: Apr-2004
 
 
 
Tracing Your Baltic, Scandinavian, Eastern European, & Middle Eastern Ancestry Online : Finnish, Swedish, Norwegian, Danish, Icelandic, Estonian, Latvian, Polish, Lithuanian, Greek, Macedonian, Bulgarian, Armenian, Hungarian, Eastern European & Middle Eastern Genealogy (All Faiths)
Publisher's price: $14.95
Format: Paperback
Size : 6 x 9
Pages: 186
ISBN: 0-595-35773-3
Published: Jun-2005
 
 
Creative Genealogy Projects: Writing Salable Life Stories
Publisher's price: $16.95
Format: Paperback
Size : 6 x 9
Pages: 187
ISBN: 0-595-31305-1
Published: Feb-2004
 
 
 
Publisher's price: $24.95
Format: Paperback
Size : 6 x 9
Pages: 368
ISBN: 0-595-29067-1
Published: Aug-2003
 
 
How to Safely Tailor Your Food, Medicines, & Cosmetics to Your Genes: A Consumer's Guide to Genetic Testing Kits from Ancestry to Nourishment
Publisher's price: $23.95
Format: Paperback
Size : 6 x 9
Pages: 352
ISBN: 0-595-29403-0
Published: Oct-2003
 
 
Publisher's price: $19.95
Format: Paperback
Size : 6 x 9
Pages: 294
ISBN: 0-595-31663-8
Published: Apr-2004

My MtDNA

How is my MtDNA Distributed Geographically?

Here are my high and low resolution mtDNA test results. (mtDNA refers to prehistoric, ancient, and current female lineage markers found in my mitochondrial DNA today.)

Haplogroup H, Sub-Haplogroup H1b: Post Ice Age Origin: East Coast of Baltic Sea; Pan-European Distribution in Current Times, found from Iceland to Bashkortostan. During Ice Age: Expanded from Spain/France 21,000 years ago to E. Baltic Sea Coast by 10,000 years ago.

Here's how one genetics scientist and author, Dr. Richard Villems, answered my question about where my mtDNA possibly could have originated. Thank you, Dr. Villems for responding to my email query. Dr. Richard Villems MD, PhD,  is Professor, IMCB; Director, EBC, Dept. of Evolutionary Biology, Tartu University. The Molecular Anthropology Group consists of researchers and students from the Estonian Biocentre and the Department of Evolutionary Biology, IMCB of Tartu University, Estonia.

 Question: Would your database perhaps have the name of a country that has the most Hb1 sequences?


Scientist's Comment on My mtDNA Possible Origins
----- Original Message -----
From: "Richard Villems"
To: "Anne Hart"
Sent: Sunday, January 23, 2005 10:53 PM
Subject: Re: query about your mtDNA database

Dear AH:
 
By far the most comprehensive table for H1b frequencies you can find in Loogvali et al, Table S2 (electronic supplement). I add here PDF file of it. Indeed - the highest you can find in Latvia/Estonia/Lithuania region, but that should not be confused with the origin of any particular mtDNA that has such a sequence. It gives just a slight hint, somewhat higher probability. But it is also in Poland, Austria, Sweden, N. Ireland, Russia, the Ukraine - wherever.
 
The origin, in its strict sense, is not something that you can deduce from frequencies alone. An educated guess needs frequency plus diversity.

Furthermore - H1b seems to be rather old - before Holocene. And that means that it has hardly started here in the east Baltics - this part of Europe was under the ice at that time.   

There is no powerful HVS 1+2 table covering Europe and these few HVS 2 mutations you have there are not informative enough to help to pinpoint its phylogeographic origin either. Perhaps a very powerful complete
sequence d-base of H1b haplos would allow to go further in such details - but   nobody is doing that at present. By far too expensive.


My mtDNA sequences: Haplogroup H1b.

HVR1 Haplogroup

H

HVR1 Mutations

16189C

 

16356C

 

16362C

 

16519C

HVR2 Mutations

263G

 

309.1C

 

315.1C

 

523-

 

524-

Here is Where my mtDNA Appears Currently Geographically on Maps, according to a report sent to me from Roots for Real, London.

Individuals           Co-ordinates          Details

1                42.67N 23.30E Bulgarian

1                51.50N 0.17W White Caucasian, England & Wales

1                52.25N 21.00E Pole living in Germany

1                52.00N 7.50E Munster area, Germany

1                41.17N 8.63W Portugal north of Douro, 20

1                38.72N 9.13W central Portugal between Douro and Tejo, 21

1                47.27N 11.40E Innsbruck, Austria

1                53.15N 18.00E Bydgoszcz (Bromberg) region between Pomerania and Kujawy, Poland

1                53.15N 18.00E Bydgoszcz (Bromberg) region between Pomerania and Kujawy, Poland

1                53.15N 18.00E Bydgoszcz (Bromberg) region between Pomerania and Kujawy, Poland

1                47.98N 7.85E Freiburg, S Germany

1                57.90N 5.17W Scotland (NW coast) EMBL:AY024788

1                55.83N 3.07W mainland Scotland EMBL:AY025191

1                55.83N 3.07W mainland Scotland EMBL:AY024734

1                55.83N 3.07W mainland Scotland EMBL:AY024537

1                59.92N 10.75E Oslo, Norway EMBL:AY025926

1                59.92N 10.75E Oslo, Norway EMBL:AY025925

1                59.92N 10.75E Oslo, Norway EMBL:AY025924

1                51.50N 0.17W England EMBL:AY025564

1                64.15N 21.85W Iceland, accno AF236959

1               40.40N 3.68W Spain

_________________________________________________________________________________________

 Why is my mtDNA so widespread?

The more ancient my mtDNA is, the farther it had the chance to expand from its original geographic location. After the Ice Age ended, my mtDNA had the chance to mutate in the past 10,000 years. It then expanded in a geographic area. This MtDNA currently is located mostly in Northern and Central Europe and Finland as well as the Baltic Sea areas, Norway and Scotland. It also is found in a wide range of European countries from Iceland to the Urals.

 __________________________________________________________________    

Directory of DNA-Testing Companies

Family Tree DNA (click on link)

1. Family Tree DNA - Genealogy by Genetics, Ltd.
World Headquarters
1919 North Loop West, Suite 110 Houston, Texas 77008, USA
Phone: (713) 868-1438 | Fax: (832) 201-7147

2. Trace Genetics LLC

PO Box 2010

Davis, CA 95617

http://www.tracegenetics.com

3. Title:  Paternity DNA Testing By paternitytesters.com.

Description: Paternitytesters.com- Paternity Testing Laboratory offering AABB DNA Paternity Testing, Cheap Prices & Free DNA Banking Worldwide. For Confidential Results in 5 days, call 866-273-8323.


If you want to get at the roots of your ancestry through studies in population genetics, read the article that will take you back before there were borders or organized religions titled, “Tracing European Founder Lineages in the Near Eastern mtDNA Pool.” Martin Richards, Vincent Macaulay, et al. American Journal of Human Genetics, 67: 1251-1276, 2000. See where our mothers really came from. (The term “our mothers” refers to the human race.)

You’ll notice in the articles you read that the British often use the term “Near Eastern” and that the Americans use the term “Middle Eastern” for the same area. Make time capsules of your DNA information for future generations to look back at their ancestor’s medical histories and genetic data. Put in explanations of how to interpret your tests and printouts or reports.

            Perhaps you want to find out the percentage of various races in your ancestry. How do know where to begin your journey into the past and future? What if you’re a foundling, an orphan, or have no knowledge of your own ethnicity? Can a DNA test at least tell you how many races are in your recent or ancient past? What facts do genetic markers really tell you about ancestry?

            If you want to start your ancestry search with DNA testing, first you take the DNA tests along with tests of racial percentages if you desire. Even your DNA has a cultural component to its molecular biology. Then you interpret the results making the complex easy to understand for yourself or your clients. Your DNA testing service can help you find answers. So can many Web sites as well as this book and other books recommended here.

            Next in your family history search, you collect letters, diaries, oral history transcriptions, home sources, artifacts, memorabilia, Census research, wills-and-probate records, medical histories, land records, slave ownership records, if it applies to your or your client. Pay particular attention to social histories to fill some gaps left by lack of women’s records.

            Search through church, synagogue, mosque, pagoda, or temple records, vital records from the US government such as military records, social security information, and government pensions for retired government employees, employment and tax records, if any exist and are available. Check school records from elementary through college, if any, social histories, ethnic histories, and religious school records.

Go to the family history Web sites, the ships’ passenger lists. I highly recommend a book for searching women’s ancestry, titled, Discovering Your Female Ancestors, by Sharon DeBartolo Carmack, Betterway Books, Ohio 1998, ISBN # 1-55870-472-8. The book’s subtitle emphasizes “Special strategies for uncovering hard-to-find information about your female lineage.”

            Marriage records often were in different languages representing the former country or languages of the ethnic group. You may need to translate a different alphabet to find a maiden name on a marriage certificate never registered, but obtained from clergy.

            Then you review and analyze the records. Study the social history of the times and location of this individual. Add family history and migrations to social history, and you have the beginnings of an outline to write a biography of the ancestor as a family history.

            Learn to interpret the results of your own DNA test and expand your historical research ability to trace your ancestry. “An interesting idea was expressed by a colleague from Canada, Dr. Charles Scriver,” explains geneticist, Dr. Batsheva Bonné-Temir. “At a meeting which I organized here in Israel on Genetic Diversity Among Jews in 1990, Dr. Scriver gave a paper on ‘What Are Genes Like that Doing in a Place Like This? Human History and Molecular Prosopography.’

“He claimed that a biological trait has two histories, a biological component and a cultural component.” Dr. Charles Scriver is founder of the DeBelle Laboratory of Biochemical Genetics in Canada. He also established screening programs in Montreal for thalassaemia and Tay Sachs Disease.”

According to Bonné-Tamir, at the 1990 meeting in Israel on Genetic Diversity Among Jews, Dr. Charles Scriver stated, “When the event clusters and an important cause of it is biological, the cultural history also is likely to be important because it may explain why the persons carrying the gene are in the particular place at the time.”

            The term, “when the event clusters” refers to an event when genes cluster together in a DNA test because the genes are similar in origin, that is, they have a common ancestral origin in a particular area, a common ancestor.

            “When I look at my own papers throughout the years,” says Bonné-Tamir. “I find that I have been quite a pioneer in realizing the significance of combining the history of individuals or of populations with their biological attributes. This is now a leading undertaking in many studies which use, for example, mutations to estimate time to the most recent ancestors and alike.”

            What lines of inquiry are used in genetics? Dr. Charles R. Scriver wrote a chapter in Batsheva Bonné-Temir’s book, titled What are genes like that doing in a place like this? Human History and Molecular Prosopography. The book title is: Genetic Diversity Among Jews: Diseases and Markers at the DNA Level. Bonné-Tamir, B. and Adam, A. Oxford University Press. 1992.

With permission, an excerpt is reprinted below from page 319:  “When a disease clusters in a particular community, two lines of inquiry follow:

1. Is the clustering caused by shared environmental exposure? Or is it explained by host susceptibility accountable to biological and/or cultural inheritance?

2. If the explanation is biological, how are the determinants inherited? These lines of inquiry imply that a disease has two different histories, one biological, the other cultural. One involves genes (heredity), pathways of development (ontogeny), and constitutional factors; the other, demography, migration and cultural practice.

            Neither history is mutually exclusive. Such thinking shifts the focus of inquiry from sick populations and incidence of disease to sick individuals and the cause of their particular disease. The person with the disease becomes the object of concern which is not the same as the disease the person has.” (Page. 319).

       Check out the chapter, “Genetics Study Identifies At-risk relatives” from Celebrating the Family published by Ancestry.com Publishing.

Check out the Web site at: http://shops.ancestry.com/product.asp?productid=2625&shopid=128.

Geneticists today are making inroads in new areas such as phenomics, nutritional genomics, and ancestral genetics. Batsheva Bonné-Tamir, PhD, http://www.tau.ac.il/medicine/USR/bonnétamirb.htm or http://www.tau.ac.il/medicine/ at Tel-Aviv University, Israel, is Head of  the National Laboratory for the Genetics of Israeli Populations (with Mia Horowitz) and Director of the Shalom and Varda Yoran Institute for Genome Research Tel-Aviv. She is also on the faculty of the Department of Human Genetics and Molecular Medicine, Sackler School of Medicine.

            Dr. Bonné-Tamir states that “One of my most impressive conclusions from the advancement in the last few years and the accumulation of knowledge in the fields of genetics and medicine, is the molecular revolution based on immense sophistication of lab techniques. This is really responsible for the recent increased emphasis on the human-social-anthropological aspects that affect biological diversity.”

            Bonné-Tamir explains, “At a meeting in 1973, in my paper on Merits and Difficulties in Studies of Middle Eastern Isolates, I said that ‘The Middle Eastern isolates have emphasized again the fertile and necessary interrelationship between history and genetics.’”

            Do historical events influence genes? “Comparative studies in population genetics are often undertaken in order to attempt reconstruction of historical and migratory movements based on gene frequencies,” says Bonné-Tamir. “The Samaritans and Karaites offer opportunities in the opposite direction, for example, to learn the influence of historical events on gene frequencies.”            

Genomic views of any ethnic group’s history are important for further study. Whether you are taking the skeptic’s position or the genomic view of your cultural history, biology does have a cultural component that needs to be analyzed scientifically. Finding flaws or benefits in research studies of any kind is the way to find inroads to truths. How else can facts change and knowledge progress?

            Molecular genealogy has joined efforts with molecular genetics. The Sorenson Molecular Genealogy Foundation (SMGF) is a nonprofit organization that was founded to build a correlated genetic and genealogical database. How can this information help you in family history research? Ugo A. Perego, MS. Senior Project Administrator, Molecular Genealogy Research Project, Brigham Young University, http://molecular-genealogy.byu.edu , and now with the Sorenson Molecular Genealogy Foundation at: http://www.smgf.org/  says, “I believe that DNA is the next thing in genealogy—the tool for the 21st century family historians.

In the past 20 years, the genealogical world has been revolutionized by the introduction of the Internet.

            “An increasing number of people are becoming interested in searching for their ancestors because through emails and websites a large world of family history information is now available to them. The greatest contribution of molecular methods to family history is the fact that in some instances family relationships and blocked genealogies can be extended even in the absence of written records.

            “Adoptions, illegitimacies, names that have been changes, migrations, wars, fire, flood, etc. are all situations in which a record may become unavailable. However, no one can change our genetic composition, which we have received by those that came before us.

             “Currently, DNA testing is an effective approach to help with strict paternal and maternal lines thanks to the analysis and comparison of the Y chromosome (male line) and mitochondrial DNA (female line) in individuals that have reason to believe the existence of a common paternal or maternal ancestor.

            “A large database of genetic and genealogical data is currently been built by the BYU Center for Molecular Genealogy and the Sorenson Molecular Genealogy Foundation. This database will contain thousands of pedigree charts and DNA from people from all over the world. Currently it has already over 35,000 participants in it.

            “The purpose of this database is to provide additional knowledge in reconstructing family lines other than the paternal and maternal, by using a large number of autosomal DNA (the DNA found in the non-sex chromosomes).

            This research, known as the Molecular Genealogy Research Project is destined to take DNA for genealogists to the next level.” For additional reading, please visit the BYU’s Molecular Genealogy Research Project’s two Web sites. Another good source of information is at http://www.relativegenetics.com, a company specialized in Y chromosome analysis for family studies.

 For further information about the Sorenson Molecular Genealogy Foundation, contact them at the following address:

Sorenson Molecular Genealogy Foundation
2511 South West Temple
Salt Lake City, UT 84115

Phone: (801) 461-9780
After hours phone: (801) 244-2542
Fax: (801) 461-9761
Email: info@smgf.org


How do you interpret family history as creative writing, and how to you interpret ancestry-related DNA tests? Thank you for the privilege of presenting this.
  Pages of Information on Interpreting DNA for Ancestry, Nutrition, Healthcare, and Family History, plus a glossary of DNA-related definitions.

To Read Excerpts from Chapters: Click Here.

Beginners who want to learn how to interpret DNA test results for family history should find this guidebook to DNA-driven genealogy an open door.
Book Description
How many DNA testing companies will show you how to interpret DNA test results for family history or direct you to instructional materials after you have had your DNA tested? Choose a company based on previous customer satisfaction, number of markers tested, and whether the company gives you choices of how many markers you want, various ethnic and geographic databases, and surname projects based on DNA-driven genealogy.

Before you select a company to test your DNA, find out how many genetic markers will be tested. For the maternal line, 400 base pairs of sequences are the minimum. For the paternal line (men only) 37 markers are great, but 25 markers also should be useful.

Some companies offer a 12-marker test for surname genealogy groups at a special price. When you order a home testing kit, you'll get mouthwash or a felt tip to rub inside your cheek and mail back.

Find out how long the turnaround time is for waiting to receive your results. What is the reputation of the company?

Do they have a contract with a university lab or a private lab? Who does the testing and who is the chief geneticist at their laboratory?

What research articles, if any, has that scientist written or what research studies on DNA have been performed by the person in charge of the DNA testing at the laboratory?

Who owns the DNA business that contracts with the lab? How involved in genealogy-related DNA projects and databases or services is the owner?

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